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10+ Health Benefits of Avocado + Side Effects

Written by Joe Cohen, BS | Last updated:

The rich, creamy texture of avocado is enjoyed all around the world whether it be in guacamole, sandwiches, or morning smoothies. But avocados are also rich in antioxidants, vitamins, minerals, and fiber that promise many potential health benefits. Read this post to learn more about the amazing health benefits of avocado.

What is Avocado?

The avocado (Persea americana) is a tree fruit native to Mexico, Central, or South America believed to first be cultivated around 500 BCE [1].

Also known as the alligator pear, the avocado is a single-seeded berry with over 25 varieties. Today, 90% of avocados consumed in the United States are of the Haas variety [2].

Avocados are mostly eaten raw in salads, sandwiches, and dips, but recently, avocado oil has become popular because of its mild flavor, high smoke point, and rich nutrient profile [1].



A typical serving of half an avocado (68g) contains 114 calories, 77% of those coming from healthy fats [1].


Compared to other fruits, avocados contain very little sugar. Half an avocado (68g) contains 6 grams of carbohydrates, but less than half a gram of sugar [1].

The glycemic index and load of avocados are believed to be zero, due to the small quantity of carbohydrates [3].

Insoluble fiber supports bowel health and regularity by adding bulk to your stool, whereas soluble fiber improves digestion by creating a gel-like substance by mixing with water. The fiber in avocado is made up of 70% insoluble and 30% soluble fiber [4, 1].

Dietary fiber is important for overall health, digestion, and disease prevention. Both soluble and insoluble fiber help regulate appetite, support healthy gut bacteria, and reduce the risk of heart disease [5, 6, 7].


The fat content in avocados consists of mostly monounsaturated fats (71%), with smaller amounts of polyunsaturated (13%) and saturated (16%) fats. Most of the monounsaturated fats in avocados are oleic acids [1].

Oleic acids are heart-healthy and can lower blood triglycerides and increase ‘good’ cholesterol (HDL) [8, 9].

Fats in avocados can also increase the absorption of fat-soluble nutrients like carotenoids in the gut [1].


Avocados have the highest protein content of any fruit, at less than 2 g in every half an avocado [1].

Main Beneficial Compounds

Avocados contain significant amounts of nutrients and phytochemicals, such as vitamins C, E and K1, folate, potassium, magnesium, antioxidants, carotenoids, and phytosterols.

These fruits are a good source of vitamin K1, containing 18% of the daily recommended intake. Vitamin K1 is crucial for blood clotting and bone health [10, 11].

Avocados are one of the few fruits that contain significant amounts of vitamins C and E. These antioxidant vitamins support skin health, immune function, and heart function [12, 13, 14].

Phytochemicals in avocados include carotenoids and phytosterols. According to some researchers, these chemicals may play a protective role in cancer prevention and heart disease [15].

The main carotenoid in avocado, xanthophyll, is a fat-soluble antioxidant that can lower inflammation and oxidative stress [16].

Avocados are the richest known fruit source of phytosterols, especially beta-sitosterol, which is believed to support healthy cholesterol levels and overall heart health [17].

Essential minerals in avocados (e.g., potassium and magnesium) are thought to contribute to its protective role in blood pressure control, heart health, and insulin sensitivity [18, 19, 20].

Avocado Oil

Avocado oil is made from extracting fats from the pulp of the avocado. Benefits are largely due to the high concentrations of monounsaturated fats and antioxidants.

The benefits of consuming avocado oil are similar to those of consuming the avocado fruit. Avocado oil has been associated with insulin sensitivity, reduction of inflammation, lowering cholesterol and triglyceride levels, and prevention of obesity [21, 22, 23].

Animal studies show avocado oil has the same ability as olive oil to normalize blood cholesterol in rabbits after 90 days [24].

Mechanism of Action

Certain compounds (phenolic compounds) in avocados can help prevent type 2 diabetes and oxidative stress in the pancreas [25].

Phytosterols in avocado are plant-based cholesterols. Their mechanism of action involves their ability to slow cholesterol absorption in the gut and decrease liver cholesterol production [26].

A study in human cancer cells found that the phytonutrient combination in avocados may hold the key to its anticancer effects [27].

Potential Benefits of Avocados

Avocado is considered safe to eat as food, but it has not been approved by the FDA for medical use. Never use avocado to replace something your doctor recommends or prescribes.

SelfDecode has an AI-powered app that allows you to see how avocado benefits your personal genetic predispositions. These are all based on clinical trials. The red and sad faces denote an increased genetic risk of developing conditions that avocado counteracts.

Possibly Effective For

1) Heart Health

Multiple studies (including 1 study of 87 adults with normal and high cholesterol levels and 1 study in 45 overweight/obese adults) found that an avocado-rich diet reduced total cholesterol, LDL cholesterol, and triglycerides [28, 29].

In multiple other studies, avocado-rich diets similarly reduced cholesterol [30, 28, 31].

Beta-sitosterol, a plant-based cholesterol, is found in high amounts in avocado and can lower cholesterol levels [26].

Other vitamins found in avocado include vitamin C and E. In a study of adults aged 45 to 68 years, a combination of vitamins C and E slowed the hardening of arteries (atherosclerosis) in people with high cholesterol [32].

Monounsaturated fats in avocado reduced inflammation and LDL cholesterol in 45 adult volunteers [29].

Animal Studies

An animal study found that avocado in the diet improved heart disease markers such as decreasing triglycerides and increasing HDL cholesterol after 5 weeks in male rats [33].

High potassium levels in avocados may reduce blood pressure, a major risk factor for heart attacks [34].

Polyphenols in avocados help control heart disease by reversing chronic and acute inflammation [35].

Avocados are high in the B vitamin folate, which helps lower blood homocysteine, a predictor of heart disease [36].

2) Metabolic Syndrome

Of the many biomarkers for metabolic syndrome, avocado has the best capacity to improve HDL cholesterol, LDL cholesterol, and total cholesterol [37].

A study of over 17,000 adults found that the consumption of half an avocado per day decreased the risk of metabolic syndrome by 50% [2]

Insufficient Evidence For

The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of avocado for any of the below-listed uses. Remember to talk to your doctor before making sudden, drastic changes to your diet, and never use avocado to replace something your doctor recommends or prescribes.

3) Diabetes

The antioxidant, fat, and dietary fiber content in avocados can help normalize blood sugar levels and lower the risk of diabetes [37].

In a study of 26 overweight adults, eating half an avocado a day resulted in lower blood insulin levels [38].

A study using pancreatic rat cells found that avocado pulp extracts could inhibit key enzymes (α-amylase and α-glucosidase) linked to type 2 diabetes [25].

Avocado oil was found to improve insulin sensitivity by 96% in rats fed a high sucrose diet [39].

4) Depression

Dietary fat quality and type play significant roles in brain function. Monounsaturated fats found in avocados have anti-inflammatory properties that may lower the risk of depression [40].

Multiple studies (a study of adults aged 55 to 85 years and a study of over 12,000 adults) found that the anti-inflammatory nature of monounsaturated fats was associated with a lower risk of depression [41, 40].

Many studies have confirmed the association between folate deficiency and depression. Foods like avocado that are high in folate may help reduce the risk of depression by preventing the buildup of homocysteine in the brain [42, 43].

5) Aging

Two clinical studies (a study with 82 males and a 14-day dietary intervention with 37 women) suggested that xanthophylls in avocados may protect against DNA damage and support healthy aging [44, 45].

Antioxidants in avocados may help reduce oxidative damage and may prevent Parkinson’s and Alzheimer’s diseases [46].

A study testing the effects of eating 1 avocado per day in 20 healthy subjects for 6 months found improvement in memory, attention span, and problem-solving compared to control groups [47].

Avocados have the highest fat-soluble antioxidant content in any fruit or vegetable. The primary antioxidant carotenoid in avocados is xanthophyll [48, 1].

6) Weight Management

Fruits such as avocados that are high in fiber and healthy fats are believed to increase satiety and help support a healthy weight.

Several preliminary clinical studies suggest that avocados help support a healthy weight. Avocado consumption is also associated with improved diet quality and nutrient intake [2].

In a study of 55 adults, the group fed one and a half avocado per day (200 g/day) for 6 weeks showed decreased body weight, body mass index, and percentage of body fat [49].

Another study of 26 healthy overweight adults found that half an avocado consumed at lunch reduced hunger by 28% and 40% for 3 or 5 hours, respectively [38].

7) Healthy Skin

The high-fat content and antioxidant properties of avocados can play an important role in maintaining healthy skin.

Lutein and zeaxanthin are found in human skin and are obtained from eating foods such as avocado. These antioxidants may help protect the skin from UV and visible radiation damage [50].

Clinical trials (1 study of 40 healthy women and 1 study of 30 dry-skinned elderly volunteers) indicated that both the topical and oral intake of lutein and zeaxanthin can improve skin elasticity, hydration, and wrinkles [51, 52].

A pilot study suggested that both the topical use and dietary intake of avocado may enhance wound healing in rats [53].

8) Pregnancy and Development

Avocados are high in fiber, monounsaturated fats, and antioxidants (lutein). These nutrients are linked to improvements in fertility, maternal health, birth outcomes, and breast milk production in premenopausal women [54, 3].

The lutein content in breast milk rises with maternal diet. This antioxidant supports proper eye and neural development in infants [55, 56].

Monounsaturated fats are necessary for brain development in the first year of life [57].

Nutrients such as folate are essential for fetal health to prevent neural and heart defects. One half an avocado contains 60 μg folate, providing 10% of the recommended daily intake for pregnant women [3].

Avocados may help expectant mothers overcome nausea due to their high B6 vitamin content, a known therapeutic approach to minimize morning sickness [58].

If you are pregnant, please consult your doctor before making sudden, drastic changes to your diet.

9) Eye Health

The antioxidants lutein and zeaxanthin found in avocado may play a role in reducing the development and progression of age-related macular degeneration [59].

Prospective cohort studies (one of 5,604 adults aged 58 to 69 years and the other 899 adults over 60 years) found that diets rich in monounsaturated fats and zeaxanthin were protective against cataract and maculopathy [60, 61].

10) Bones and Joints

Half of an avocado provides approximately 25% of the daily recommended intake of vitamin K1. Vitamin K1 can support bone health by increasing calcium absorption and reducing urine calcium levels [62].

A community-based cohort study of 293 healthy adults with an average age of 58 years found that antioxidants common in avocados (lutein and zeaxanthin) were associated with a decreased risk of cartilage defects, common symptoms of osteoarthritis [63].

Animal Research (Lacking Evidence)

No clinical evidence supports the use of avocado for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

11) Blood Pressure

Avocados are a rich source of potassium, which relaxes the walls of blood vessels, thereby lowering blood pressure (hypertension) [64].

The monounsaturated fats in avocados may be able to reduce blood pressure in the short and long-term [8].

The high fiber content of avocado may also contribute to the prevention of high blood pressure, especially in populations where fiber intake is below recommended levels [65].

12) Liver Health

Antioxidants in avocados could potentially protect against liver injury [66].

In a rat study, the avocado was able to minimize liver injury, suggesting a potential role of this fruit in the prevention of liver disease [67].

13) Gut Health

The high content of soluble and insoluble fiber and fats in avocados helps to maintain a healthy digestive system by reducing symptoms of constipation and diarrhea. The high fiber content can also provide a prebiotic food source for healthy gut bacteria, improving overall digestion and preventing symptoms of irritable bowel syndrome-like diarrhea [68].

14) Infectious Disease

Defensin, a protein found in avocado extracts, has antimicrobial properties against Escherichia coli and Staphylococcus aureus, suggesting a potential future use in the treatment of infectious diseases [69].

Cancer Research

A survey of adults over 20 years found that blood carotenoid concentrations were associated with reduced mortality from digestive cancers such as esophageal, colon, and pancreatic cancer [70].

In a study, phytochemicals found in avocados (lutein and xanthophylls) reduced oxidative stress in 52 patients treated for early-stage head and neck cancer [71].

Cell Studies

Avocados have a high concentration of phytochemicals, including carotenoids, which may prevent cancer by increasing cell death in precancerous and cancerous cells [72].

Carotenoids and antimicrobial proteins (e.g., defensin) in avocados have high antioxidant activity and can stimulate breast cancer cell death [73, 74].

A nested case-control study of women found that total carotenoids in the blood were associated with reduced breast cancer risk, especially in women with dense breast tissue [75].

Carotenoid extracts from avocado can inhibit prostate cancer cell growth [76].

Glutathione, a potent antioxidant, is several folds higher in avocado than in most other fruit. A case-control study found a significant, albeit weak, link between increased glutathione and decreased risk of oral cancer [77, 78].

Avocado extracts induced cell death in human oral cancer cell lines [79].

Side Effects & Safety

Avocado Allergy

An oral allergy to avocado may result in mild to severe allergic responses including itching of lips, mouth, and throat, usually within 1 hour of consuming or handling avocado.

There may be a higher likelihood of an avocado allergy if a birch pollen or latex allergy is present. This is because of the similarity of allergens present in avocados, natural latex, and pollen.

Symptoms tend to be more severe in a latex-avocado allergy and include abdominal pain, vomiting, and at times, anaphylaxis [80].

Digestive Upset

The avocado contains fermentable oligo-, di-, monosaccharides and polyols (FODMAPs). These fermentable carbohydrates may trigger symptoms related to irritable bowel syndrome (IBS) such as abdominal pain, bloating, and diarrhea [81].


Avocados contain small amounts of tyramine, a breakdown product of the amino acid tyrosine, which has been linked to migraine headaches [82].

Drug Interactions

Avocados are high in vitamin K1, a potent blood clotting nutrient [1].

Blood thinner medications, such as warfarin, act by blocking vitamin K1 activity. The dose of warfarin will fluctuate significantly depending on the amount of vitamin K1 in the diet [83].

The level of vitamin K1 in one ounce of avocado is 150 times lower than the amount of vitamin K1 expected to interfere with the anticoagulant effect of warfarin [84, 85].

To avoid adverse effects and unexpected interactions, talk to your doctor before making any sudden, drastic changes in your diet. If you experience allergic symptoms after eating avocado for the first time, seek medical attention immediately.

Can Animals Eat Avocado?

Avocado contains persin, a fungicidal toxin that is relatively harmless for humans but may be toxic to domestic animals such as cattle, horses, goats, birds, and fish. While dogs are more resistant than most other animals, avocado is not entirely safe and may cause vomiting and diarrhea.

The biggest danger from persin comes from the avocado seed. If you suspect your dog has swallowed an avocado pit, call your vet immediately.

About the Author

Joe Cohen, BS

Joe Cohen, BS

Joe Cohen flipped the script on conventional and alternative medicine…and it worked. Growing up, he suffered from inflammation, brain fog, fatigue, digestive problems, insomnia, anxiety, and other issues that were poorly understood in traditional healthcare. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. Based on his own health success, he went on to found SelfDecode, the world’s first direct-to-consumer DNA analyzer & precision health tool that utilizes AI-driven polygenic risk scoring to produce accurate insights and health recommendations. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs.
Joe is a thriving entrepreneur, with a mission to empower people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time. 


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